diff --git a/packages/react-native/Libraries/BatchedBridge/MessageQueue.js b/packages/react-native/Libraries/BatchedBridge/MessageQueue.js
index 2d0a98f2601..97ea2ca70b8 100644
--- a/packages/react-native/Libraries/BatchedBridge/MessageQueue.js
+++ b/packages/react-native/Libraries/BatchedBridge/MessageQueue.js
@@ -57,7 +57,8 @@ class MessageQueue {
   __spy: ?(data: SpyData) => void;
 
   constructor() {
-    this._lazyCallableModules = {};
+    // $FlowFixMe[incompatible-type] Object.create(null) is used as a string-keyed map.
+    this._lazyCallableModules = Object.create(null);
     this._queue = [[], [], [], 0];
     this._successCallbacks = new Map();
     this._failureCallbacks = new Map();
diff --git a/packages/react-native/Libraries/BatchedBridge/__tests__/MessageQueue-itest.js b/packages/react-native/Libraries/BatchedBridge/__tests__/MessageQueue-itest.js
index af908a23284..6b27b521c71 100644
--- a/packages/react-native/Libraries/BatchedBridge/__tests__/MessageQueue-itest.js
+++ b/packages/react-native/Libraries/BatchedBridge/__tests__/MessageQueue-itest.js
@@ -137,6 +137,18 @@ describe('MessageQueue', () => {
     expect(queue.getCallableModule(name)).toEqual(dummyModule);
   });
 
+  it('should not return inherited Object properties as callable modules', () => {
+    expect(queue.getCallableModule('constructor')).toBeNull();
+    expect(queue.getCallableModule('__proto__')).toBeNull();
+  });
+
+  it('should register callable modules named __proto__', () => {
+    const dummyModule = {};
+    queue.registerCallableModule('__proto__', dummyModule);
+
+    expect(queue.getCallableModule('__proto__')).toBe(dummyModule);
+  });
+
   it('should not initialize lazily registered module before it was used for the first time', () => {
     const dummyModule = {},
       name = 'modulesName';