diff --git a/Lib/test/test_wsgiref.py b/Lib/test/test_wsgiref.py
index d24aaab1327409..a1e334c7ffd853 100644
--- a/Lib/test/test_wsgiref.py
+++ b/Lib/test/test_wsgiref.py
@@ -849,6 +849,13 @@ def write(self, b):
         self.assertIsNotNone(h.status)
         self.assertIsNotNone(h.environ)
 
+    def testRaisesControlCharacters(self):
+        for c0 in control_characters_c0():
+            with self.subTest(c0):
+                base = BaseHandler()
+                headers = [('x','y')]
+                self.assertRaises(ValueError, base.start_response, f"{c0}", headers)
+
 
 class TestModule(unittest.TestCase):
     def test_deprecated__version__(self):
diff --git a/Lib/wsgiref/handlers.py b/Lib/wsgiref/handlers.py
index 9353fb678625b3..dfb712cdb5f8cb 100644
--- a/Lib/wsgiref/handlers.py
+++ b/Lib/wsgiref/handlers.py
@@ -3,7 +3,7 @@
 from .util import FileWrapper, guess_scheme, is_hop_by_hop
 from .headers import Headers
 
-import sys, os, time
+import sys, os, time, re
 
 __all__ = [
     'BaseHandler', 'SimpleHandler', 'BaseCGIHandler', 'CGIHandler',
@@ -16,6 +16,9 @@
               "Jan", "Feb", "Mar", "Apr", "May", "Jun",
               "Jul", "Aug", "Sep", "Oct", "Nov", "Dec"]
 
+_name_disallowed_re = re.compile(r'[\x00-\x1F\x7F]')
+_value_disallowed_re = re.compile(r'[\x00-\x08\x0A-\x1F\x7F]')
+
 def format_date_time(timestamp):
     year, month, day, hh, mm, ss, wd, y, z = time.gmtime(timestamp)
     return "%s, %02d %3s %4d %02d:%02d:%02d GMT" % (
@@ -237,13 +240,13 @@ def start_response(self, status, headers,exc_info=None):
 
         self.status = status
         self.headers = self.headers_class(headers)
-        status = self._convert_string_type(status, "Status")
+        status = self._convert_string_type(status, "Status", name=True)
         self._validate_status(status)
 
         if __debug__:
             for name, val in headers:
-                name = self._convert_string_type(name, "Header name")
-                val = self._convert_string_type(val, "Header value")
+                name = self._convert_string_type(name, "Header name", name=True)
+                val = self._convert_string_type(val, "Header value", name=False)
                 assert not is_hop_by_hop(name),\
                        f"Hop-by-hop header, '{name}: {val}', not allowed"
 
@@ -257,9 +260,12 @@ def _validate_status(self, status):
         if status[3] != " ":
             raise AssertionError("Status message must have a space after code")
 
-    def _convert_string_type(self, value, title):
+    def _convert_string_type(self, value, title, *, name):
         """Convert/check value type."""
         if type(value) is str:
+            regex = (_name_disallowed_re if name else _value_disallowed_re)
+            if regex.search(value):
+                raise ValueError("Control characters not allowed in header names, values and statuses")
             return value
         raise AssertionError(
             "{0} must be of type str (got {1})".format(title, repr(value))
diff --git a/Misc/NEWS.d/next/Security/2026-01-31-21-56-54.gh-issue-144370.fp9m8t.rst b/Misc/NEWS.d/next/Security/2026-01-31-21-56-54.gh-issue-144370.fp9m8t.rst
new file mode 100644
index 00000000000000..133a02a0b3fefd
--- /dev/null
+++ b/Misc/NEWS.d/next/Security/2026-01-31-21-56-54.gh-issue-144370.fp9m8t.rst
@@ -0,0 +1 @@
+Disallow usage of control characters in header names, values and statuses in ``Lib/wsgiref/handlers.py`` for security. Patch by Benedikt Johannes.