diff --git a/src/main/java/io/github/guacsec/trustifyda/providers/PythonPipProvider.java b/src/main/java/io/github/guacsec/trustifyda/providers/PythonPipProvider.java
index 72bd2b0d..bfe021c8 100644
--- a/src/main/java/io/github/guacsec/trustifyda/providers/PythonPipProvider.java
+++ b/src/main/java/io/github/guacsec/trustifyda/providers/PythonPipProvider.java
@@ -210,6 +210,11 @@ private static String extractDepFull(String requirementLine) {
   }
 
   private String[] splitToNameVersion(String nameVersion) {
+    // Strip PEP 508 environment markers (everything after ";")
+    int markerIndex = nameVersion.indexOf(';');
+    if (markerIndex != -1) {
+      nameVersion = nameVersion.substring(0, markerIndex).trim();
+    }
     String[] result;
     if (nameVersion.matches(
         "[a-zA-Z0-9-_()]+={2}[0-9]{1,4}[.][0-9]{1,4}(([.][0-9]{1,4})|([.][a-zA-Z0-9]+)|([a-zA-Z0-9]+)|([.][a-zA-Z0-9]+[.][a-z-A-Z0-9]+))?")) {
diff --git a/src/main/java/io/github/guacsec/trustifyda/utils/PythonControllerBase.java b/src/main/java/io/github/guacsec/trustifyda/utils/PythonControllerBase.java
index cc367bc1..67d92569 100644
--- a/src/main/java/io/github/guacsec/trustifyda/utils/PythonControllerBase.java
+++ b/src/main/java/io/github/guacsec/trustifyda/utils/PythonControllerBase.java
@@ -388,31 +388,24 @@ public static String getDependencyName(String dep) {
         requirement = requirement.substring(0, extrasStart) + requirement.substring(extrasEnd + 1);
       }
     }
-    int rightTriangleBracket = requirement.indexOf(">");
-    int leftTriangleBracket = requirement.indexOf("<");
-    int equalsSign = requirement.indexOf("=");
-    int minimumIndex = getFirstSign(rightTriangleBracket, leftTriangleBracket, equalsSign);
+    // Find the first PEP 508 version operator character (~=, !=, ==, >=, <=, >, <, ===)
+    int firstOperatorChar = -1;
+    for (int i = 0; i < requirement.length(); i++) {
+      char c = requirement.charAt(i);
+      if (c == '>' || c == '<' || c == '=' || c == '~' || c == '!') {
+        firstOperatorChar = i;
+        break;
+      }
+    }
     String depName;
-    if (rightTriangleBracket == -1 && leftTriangleBracket == -1 && equalsSign == -1) {
+    if (firstOperatorChar == -1) {
       depName = requirement;
     } else {
-      depName = requirement.substring(0, minimumIndex);
+      depName = requirement.substring(0, firstOperatorChar);
     }
     return depName.trim();
   }
 
-  private static int getFirstSign(
-      int rightTriangleBracket, int leftTriangleBracket, int equalsSign) {
-    rightTriangleBracket = rightTriangleBracket == -1 ? 999 : rightTriangleBracket;
-    leftTriangleBracket = leftTriangleBracket == -1 ? 999 : leftTriangleBracket;
-    equalsSign = equalsSign == -1 ? 999 : equalsSign;
-    return equalsSign < leftTriangleBracket && equalsSign < rightTriangleBracket
-        ? equalsSign
-        : (leftTriangleBracket < equalsSign && leftTriangleBracket < rightTriangleBracket
-            ? leftTriangleBracket
-            : rightTriangleBracket);
-  }
-
   static List<String> splitPipShowLines(String pipShowOutput) {
     return Arrays.stream(
             pipShowOutput.split(System.lineSeparator() + "---" + System.lineSeparator()))
diff --git a/src/test/java/io/github/guacsec/trustifyda/providers/Python_Provider_Test.java b/src/test/java/io/github/guacsec/trustifyda/providers/Python_Provider_Test.java
index 2f6cce69..c9580e54 100644
--- a/src/test/java/io/github/guacsec/trustifyda/providers/Python_Provider_Test.java
+++ b/src/test/java/io/github/guacsec/trustifyda/providers/Python_Provider_Test.java
@@ -267,6 +267,39 @@ void Test_The_ProvideComponent_Path_Should_Throw_Exception() {
         .isThrownBy(() -> new PythonPipProvider(Path.of(".")).provideComponent());
   }
 
+  @Test
+  void getIgnoredDependencies_strips_environment_markers() throws IOException {
+    Path tempFile = Files.createTempFile("requirements", ".txt");
+    try {
+      Files.writeString(
+          tempFile,
+          String.join(
+              System.lineSeparator(),
+              "requests==2.25.1 ; python_version >= \"3.6\" #trustify-da-ignore",
+              "idna==2.10 ; python_version >= \"3.6\" # trustify-da-ignore",
+              "six==1.16.0 ; python_version < \"3.0\" or python_version >= \"3.3\""
+                  + " #trustify-da-ignore",
+              "chardet==4.0.0 ; python_version >= \"3.6\" and sys_platform == \"linux\""
+                  + " #trustify-da-ignore",
+              "flask==2.0.3"));
+      var provider = new PythonPipProvider(tempFile);
+      var ignored = provider.getIgnoredDependencies(Files.readString(tempFile));
+      var ignoredMap =
+          ignored.stream()
+              .collect(
+                  java.util.stream.Collectors.toMap(
+                      com.github.packageurl.PackageURL::getName,
+                      com.github.packageurl.PackageURL::getVersion));
+      assertThat(ignoredMap).containsEntry("requests", "2.25.1");
+      assertThat(ignoredMap).containsEntry("idna", "2.10");
+      assertThat(ignoredMap).containsEntry("six", "1.16.0");
+      assertThat(ignoredMap).containsEntry("chardet", "4.0.0");
+      assertThat(ignoredMap).doesNotContainKey("flask");
+    } finally {
+      Files.deleteIfExists(tempFile);
+    }
+  }
+
   private String dropIgnored(String s) {
     return s.replaceAll("\\s+", "").replaceAll("\"timestamp\":\"[a-zA-Z0-9\\-\\:]+\"", "");
   }
diff --git a/src/test/java/io/github/guacsec/trustifyda/utils/PythonControllerRealEnvTest.java b/src/test/java/io/github/guacsec/trustifyda/utils/PythonControllerRealEnvTest.java
index ee63d5d1..4aa98d2c 100644
--- a/src/test/java/io/github/guacsec/trustifyda/utils/PythonControllerRealEnvTest.java
+++ b/src/test/java/io/github/guacsec/trustifyda/utils/PythonControllerRealEnvTest.java
@@ -301,6 +301,16 @@ void get_Dependency_Name_with_markers() {
         PythonControllerRealEnv.getDependencyName("certifi==2023.7.22 ; python_version >= \"3\""));
   }
 
+  /** Verifies getDependencyName handles compatibility (~=) and exclusion (!=) operators. */
+  @Test
+  void get_Dependency_Name_with_compatibility_and_exclusion_operators() {
+    assertEquals("urllib3", PythonControllerRealEnv.getDependencyName("urllib3~=1.26.0"));
+    assertEquals("click", PythonControllerRealEnv.getDependencyName("click!=7.1.1"));
+    assertEquals("certifi", PythonControllerRealEnv.getDependencyName("certifi>=2021.0.0"));
+    assertEquals("package", PythonControllerRealEnv.getDependencyName("package~=2.0"));
+    assertEquals("package", PythonControllerRealEnv.getDependencyName("package!=1.0.0"));
+  }
+
   /** Verifies getDependencyName strips PEP 508 extras from requirements. */
   @Test
   void get_Dependency_Name_with_extras() {
@@ -313,6 +323,17 @@ void get_Dependency_Name_with_extras() {
             "package[extra1]>=1.0 ; python_version >= \"3.8\""));
   }
 
+  /** Verifies getDependencyName handles extras combined with special version operators. */
+  @Test
+  void get_Dependency_Name_with_extras_and_special_operators() {
+    assertEquals(
+        "requests", PythonControllerRealEnv.getDependencyName("requests[security,socks]==2.25.1"));
+    assertEquals("httpx", PythonControllerRealEnv.getDependencyName("httpx [http2] >=0.23.0"));
+    assertEquals(
+        "package",
+        PythonControllerRealEnv.getDependencyName("package[extra]~=1.0 ; python_version >= \"3\""));
+  }
+
   @Test
   void automaticallyInstallPackageOnEnvironment() {
     assertFalse(pythonControllerRealEnv.automaticallyInstallPackageOnEnvironment());