diff --git a/.github/workflows/run-regression-high-performance.yml b/.github/workflows/run-regression-high-performance.yml
index 0928f82f1..b54b2d108 100644
--- a/.github/workflows/run-regression-high-performance.yml
+++ b/.github/workflows/run-regression-high-performance.yml
@@ -683,7 +683,7 @@ jobs:
     with:
       suite_name: iceberg
       part: 1
-      timeout_minutes: 180
+      timeout_minutes: 300
       storage_path: /iceberg
       regression_args: '--only "/iceberg/iceberg engine/rest catalog/*" "/iceberg/s3 table function/*" "/iceberg/icebergS3 table function/*" "/iceberg/iceberg cache/*"'
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
@@ -703,7 +703,7 @@ jobs:
     with:
       suite_name: iceberg
       part: 2
-      timeout_minutes: 180
+      timeout_minutes: 300
       storage_path: /iceberg 
       regression_args: '--only "/iceberg/iceberg engine/glue catalog/*" "/iceberg/iceberg table engine/*"'
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
@@ -844,7 +844,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: lightweight_delete
-      timeout_minutes: 180
+      timeout_minutes: 300
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -878,7 +878,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: parquet
-      timeout_minutes: 180
+      timeout_minutes: 300
       storage_path: /no_s3
       ref: ${{ inputs.ref }}
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
@@ -1012,7 +1012,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: rbac
-      timeout_minutes: 180
+      timeout_minutes: 300
       part: 1
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
@@ -1030,7 +1030,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: rbac
-      timeout_minutes: 180
+      timeout_minutes: 300
       part: 2
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
@@ -1048,7 +1048,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: rbac
-      timeout_minutes: 180
+      timeout_minutes: 300
       part: 3
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
@@ -1356,7 +1356,7 @@ jobs:
     with:
       suite_name: ssl_server
       part: 1
-      timeout_minutes: 180
+      timeout_minutes: 300
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -1374,7 +1374,7 @@ jobs:
     with:
       suite_name: ssl_server
       part: 2
-      timeout_minutes: 180
+      timeout_minutes: 300
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -1392,7 +1392,7 @@ jobs:
     with:
       suite_name: ssl_server
       part: 3
-      timeout_minutes: 180
+      timeout_minutes: 300
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
diff --git a/aggregate_functions/regression.py b/aggregate_functions/regression.py
index 50cf08fdc..c65b57849 100755
--- a/aggregate_functions/regression.py
+++ b/aggregate_functions/regression.py
@@ -851,17 +851,27 @@ def regression(
             order_by="tuple()",
         )
 
+    with And("I increase query timeouts for sanitizer builds"):
+        if check_with_any_sanitizer(self):
+            default_query_settings = getsattr(
+                current().context, "default_query_settings", []
+            )
+            # MSAN builds are very slow, need longer timeouts for data insertion
+            default_query_settings.append(("receive_timeout", 900))
+            default_query_settings.append(("send_timeout", 900))
+            self.context.default_query_settings = default_query_settings
+
     with And("I populate tables with test data"):
         self.context.table.insert_test_data(cardinality=1, shuffle_values=False)
         self.context.table_extra_data.insert_test_data(
             cardinality=5, shuffle_values=True
         )
 
-    with And("allow higher cpu_wait_ratio "):
+    with And("allow higher cpu_wait_ratio (increased for sanitizer builds)"):
         if check_clickhouse_version(">=25.4")(self):
             allow_higher_cpu_wait_ratio(
-                min_os_cpu_wait_time_ratio_to_throw=10,
-                max_os_cpu_wait_time_ratio_to_throw=20,
+                min_os_cpu_wait_time_ratio_to_throw=50,
+                max_os_cpu_wait_time_ratio_to_throw=100,
             )
 
     with Feature("part 1"):
diff --git a/alter/regression.py b/alter/regression.py
index 297fa2cdd..1795646b4 100755
--- a/alter/regression.py
+++ b/alter/regression.py
@@ -34,6 +34,29 @@ def argparser(parser):
 
 
 xfails = {
+    # Data corruption bugs exposed by sanitizer builds
+    "/alter/attach partition/*": [
+        (
+            Fail,
+            "UNKNOWN_CODEC data corruption with sanitizers - needs investigation",
+            check_with_any_sanitizer,
+        )
+    ],
+    "/alter/replace partition/*": [
+        (
+            Fail,
+            "UNKNOWN_CODEC data corruption with sanitizers - needs investigation",
+            check_with_any_sanitizer,
+        )
+    ],
+    # Merge part UINT32_MAX overflow bug
+    "/alter/attach partition/*/optimize table * final/*": [
+        (
+            Fail,
+            "https://github.com/ClickHouse/ClickHouse/issues/69001 - Merge part UINT32_MAX overflow",
+            check_with_any_sanitizer,
+        )
+    ],
     "/alter/replace partition/concurrent merges and mutations/mutations on unrelated partition": [
         (
             Fail,
diff --git a/base_58/regression.py b/base_58/regression.py
index 14f85fb5c..08d195d42 100755
--- a/base_58/regression.py
+++ b/base_58/regression.py
@@ -10,11 +10,19 @@
 
 from helpers.cluster import create_cluster
 from helpers.argparser import argparser, CaptureClusterArgs
-from helpers.common import check_clickhouse_version, experimental_analyzer
+from helpers.common import check_clickhouse_version, experimental_analyzer, check_with_any_sanitizer
 
 pr_70846 = "https://github.com/ClickHouse/ClickHouse/pull/70846"
 
 xfails = {
+    # Memory usage tests fail with sanitizers due to test code issues and memory overhead
+    "/base58/memory usage/*": [
+        (
+            Error,
+            "Memory usage tests have issues with sanitizer builds",
+            check_with_any_sanitizer,
+        )
+    ],
     "alias input/alias instead of table and column": [(Fail, "not implemented")],
     "/base58/unsupported types constant/Nullable（FixedString（3））/*": [
         (
diff --git a/helpers/cluster.py b/helpers/cluster.py
index 5cffce8b3..9491871f8 100755
--- a/helpers/cluster.py
+++ b/helpers/cluster.py
@@ -582,7 +582,7 @@ def enable_thread_fuzzer(self):
             self.command("export THREAD_FUZZER_pthread_mutex_unlock_BEFORE_SLEEP_TIME_US=10000")
             self.command("export THREAD_FUZZER_pthread_mutex_unlock_AFTER_SLEEP_TIME_US=10000")
 
-    def wait_clickhouse_healthy(self, timeout=90, check_version=True, initial_delay=0):
+    def wait_clickhouse_healthy(self, timeout=600, check_version=True, initial_delay=0):
         with By(f"waiting until ClickHouse server on {self.name} is healthy"):
             for attempt in retries(timeout=timeout, delay=5, initial_delay=initial_delay):
                 with attempt:
@@ -719,7 +719,7 @@ def stop_clickhouse(self, timeout=300, safe=True, signal="TERM"):
 
     def start_clickhouse(
         self,
-        timeout=60,
+        timeout=600,
         wait_healthy=True,
         user=None,
         thread_fuzzer=False,
@@ -778,7 +778,7 @@ def start_clickhouse(
                 if wait_healthy:
                     self.wait_clickhouse_healthy(timeout=timeout, check_version=check_version, initial_delay=2)
 
-    def restart_clickhouse(self, timeout=300, safe=True, wait_healthy=True, retry_count=5, user=None):
+    def restart_clickhouse(self, timeout=600, safe=True, wait_healthy=True, retry_count=5, user=None):
         """Restart ClickHouse server."""
         self.stop_clickhouse(timeout=timeout, safe=safe)
 
diff --git a/helpers/common.py b/helpers/common.py
index c467acf1b..ae51c3e87 100644
--- a/helpers/common.py
+++ b/helpers/common.py
@@ -56,7 +56,10 @@ def check(test):
 def check_with_ubsan(test):
     """Check if the build is with undefined behavior sanitizer (ubsan)."""
     if hasattr(test.context, "build_options"):
-        if "ubsan" in test.context.build_options.values():
+        if any(
+            node_build_options.get("sanitizer") == "ubsan"
+            for node_build_options in test.context.build_options.values()
+        ):
             return True
 
     return False
@@ -65,7 +68,10 @@ def check_with_ubsan(test):
 def check_with_tsan(test):
     """Check if the build is with thread sanitizer (tsan)."""
     if hasattr(test.context, "build_options"):
-        if "tsan" in test.context.build_options.values():
+        if any(
+            node_build_options.get("sanitizer") == "tsan"
+            for node_build_options in test.context.build_options.values()
+        ):
             return True
 
     return False
@@ -74,7 +80,10 @@ def check_with_tsan(test):
 def check_with_asan(test):
     """Check if the build is with address sanitizer (asan)."""
     if hasattr(test.context, "build_options"):
-        if "asan" in test.context.build_options.values():
+        if any(
+            node_build_options.get("sanitizer") == "asan"
+            for node_build_options in test.context.build_options.values()
+        ):
             return True
 
     return False
@@ -83,7 +92,10 @@ def check_with_asan(test):
 def check_with_msan(test):
     """Check if the build is with memory sanitizer (msan)."""
     if hasattr(test.context, "build_options"):
-        if "msan" in test.context.build_options.values():
+        if any(
+            node_build_options.get("sanitizer") == "msan"
+            for node_build_options in test.context.build_options.values()
+        ):
             return True
 
     return False
@@ -148,7 +160,9 @@ def check_with_any_sanitizer(test):
     sanitizers = ["tsan", "asan", "ubsan", "msan"]
     if hasattr(test.context, "build_options"):
         return any(
-            sanitizer in test.context.build_options.values() for sanitizer in sanitizers
+            node_build_options.get("sanitizer") == sanitizer
+            for node_build_options in test.context.build_options.values()
+            for sanitizer in sanitizers
         )
     return False
 
@@ -161,7 +175,8 @@ def check_several_sanitizers_in_binary_link(
     def check(test):
         if hasattr(test.context, "build_options"):
             return any(
-                sanitizer in test.context.build_options.values()
+                node_build_options.get("sanitizer") == sanitizer
+                for node_build_options in test.context.build_options.values()
                 for sanitizer in sanitizers
             )
         return False
diff --git a/iceberg/regression.py b/iceberg/regression.py
index 0ce195ac9..8cd13455f 100755
--- a/iceberg/regression.py
+++ b/iceberg/regression.py
@@ -17,10 +17,19 @@
     check_is_altinity_build,
     experimental_analyzer,
     check_if_antalya_build,
+    check_with_any_sanitizer,
 )
 
 
 xfails = {
+    # Server crashes with "Metadata is not initialized" during schema evolution with sanitizers
+    "/iceberg/iceberg engine/*/schema evolution/*": [
+        (
+            Fail,
+            "https://github.com/ClickHouse/ClickHouse/issues/86024 - Iceberg metadata initialization bug with sanitizers",
+            check_with_any_sanitizer,
+        )
+    ],
     "/iceberg/icebergS3 table function/recreate table/scan and display data with pyiceberg, expect empty table": [
         (Fail, "https://github.com/ClickHouse/ClickHouse/issues/87574")
     ],
@@ -193,6 +202,11 @@
 }
 
 ffails = {
+    "/iceberg/iceberg engine/*": (
+        Skip,
+        "Iceberg tests unstable with sanitizer builds (server startup issues)",
+        check_with_any_sanitizer,
+    ),
     "/iceberg/iceberg engine": (
         Skip,
         "Iceberg engine was introduced in 24.12",
diff --git a/ontime_benchmark/benchmark.py b/ontime_benchmark/benchmark.py
index 7a87da7cf..876e631e7 100755
--- a/ontime_benchmark/benchmark.py
+++ b/ontime_benchmark/benchmark.py
@@ -7,7 +7,7 @@
 append_path(sys.path, "..")
 
 from helpers.cluster import Cluster, create_cluster
-from helpers.common import check_clickhouse_version
+from helpers.common import check_clickhouse_version, check_with_any_sanitizer
 from helpers.argparser import (
     argparser_s3 as argparser_base,
     CaptureClusterArgs,
@@ -36,7 +36,13 @@
     ],
 }
 
-ffails = {}
+ffails = {
+    "/benchmark/*": (
+        Skip,
+        "Benchmark tests are too slow with sanitizer builds",
+        check_with_any_sanitizer,
+    ),
+}
 
 
 def argparser(parser):
diff --git a/rbac/regression.py b/rbac/regression.py
index e87303c1e..910da864f 100755
--- a/rbac/regression.py
+++ b/rbac/regression.py
@@ -9,7 +9,7 @@
 
 from helpers.cluster import create_cluster
 from helpers.argparser import argparser, CaptureClusterArgs
-from helpers.common import check_clickhouse_version, experimental_analyzer
+from helpers.common import check_clickhouse_version, experimental_analyzer, check_with_any_sanitizer
 from rbac.requirements import SRS_006_ClickHouse_Role_Based_Access_Control
 from rbac.helper.common import add_rbac_config_file
 
@@ -257,8 +257,8 @@
     ),
     "/rbac/part 1/privileges/system drop cache/compiled expression cache*": (
         Skip,
-        "Not supportted in ARM builds",
-        (lambda test: platform.machine() == "aarch64"),
+        "JIT compilation disabled in ARM and sanitizer builds",
+        (lambda test: platform.machine() == "aarch64" or check_with_any_sanitizer(test)),
     ),
     "rbac/part 1/privileges/:/table_type='ReplicatedReplacingMergeTree-sharded_cluster": (
         Skip,
diff --git a/settings/regression.py b/settings/regression.py
index 50dd7d7e3..1d9f35818 100755
--- a/settings/regression.py
+++ b/settings/regression.py
@@ -10,9 +10,24 @@
     CaptureClusterArgs,
 )
 
-from helpers.common import check_clickhouse_version, check_if_head
+from helpers.common import check_clickhouse_version, check_if_head, check_with_any_sanitizer
 
 xfails = {
+    # Profiler settings have different defaults in sanitizer builds (profilers disabled)
+    "/settings/default values/query_profiler_cpu_time_period_ns": [
+        (
+            Fail,
+            "Profilers are disabled in sanitizer builds",
+            check_with_any_sanitizer,
+        )
+    ],
+    "/settings/default values/query_profiler_real_time_period_ns": [
+        (
+            Fail,
+            "Profilers are disabled in sanitizer builds",
+            check_with_any_sanitizer,
+        )
+    ],
     "/settings/default values/parallel_replicas_mark_segment_size": [
         (
             Fail,